SPR Therapy

The story of NMN

<LifeSpan-Why We Age, and Why We Don't Have To> by David A. Sinclair, Ph. D.

"A NEW YORK TIMES BESTSELLER

“Brilliant and enthralling.” —The Wall Street Journal"

Gold SPR Therapy?

Advanced GOLD SPR (surface plasmon resonance) Near-infrared THERAPY


Historical Artifacts of SPR (Surface Plasmon Resonance)

The Lycurgus Cup (Rome, AD 4th)

The glass contains tiny amounts of gold and silver particles inducing SPR phenomena.


Physicochemical Properties of Gold Nanoparticles (AuNPs)-The surface plasmon effect

Benefits

AuNPs are stable (inert) and non-toxic.

AuNPs can be used in a variety of applications in biomedical fields.

Chem Asian J. 2021, 16, 720 –742
Chem Asian J. 2021, 16, 720 –742

Surface plasmon resonance (SPR) is a crucial novel optical phenomenon possessed by plasmonic Gold nanoparticles (AuNPs), which are produced by electromagnetic radiations whose electrical constituents cause the excitation of free electrons (surface electrons) in metal.

The electronic oscillation of surface electrons results in a charge separation, which in turn produces dipole oscillation that works parallel to the direction of the electric field of the electromagnetic waves. The frequency (specific) at which the amplitude of the oscillation is maximum is called SPR frequency.

The band intensity of the SPR band is greatly affected by those factors, which also affect the surface’s electron charge density, such as surface morphology, composition, dielectric environment, metal type, and particle size. In the SPR phenomenon, the collective oscillation of electrons, due to interaction between light and surface electrons, has two modes: surface plasmon–polarization (SPP) and localized surface plasmon resonance (LSPR).

AuNPs are stable (inert) and non-toxic in a wide variety of environments with controllable optoelectrical properties. Owing to these benefits, AuNPs can be used in a variety of applications ranging from the environmental and energy sectors to biomedical fields.

Gold Cloud PAR,

金云发, is based on Gold Nanoparticles Near-infrared SPR (surface plasmon resonance) technology. Gold Cloud PAR is a specially developed skin problem care solution which is an advanced gold therapy that is modified from gold PTT (photothermal therapy).RADKIN introducing GOLD CLOUD PAR based on Gold Nanoparticles Near-infrared SPR (surface plasmon resonance), the product optimized for energy devices using various lights, laser, plasma, and IPL.

GOLD NANOPARTICLES SPR

Numerous free electrons exist inside the metal, which is a conductor. Since free electrons are not bound to metal atoms, they can easily respond to specific external stimuli. In particular, when a metal becomes nano-sized, a surface plasmon resonance characteristic appears due to the behavior of such free electrons and thus has unique optical properties. Surface plasmon resonance refers to a phenomenon in which free electrons on the metal surface collectively vibrate due to resonance with an electromagnetic field of specific light energy when light is incident between the surface of a metal nanoparticle, which is a conductor, and a dielectric such as air or water. Since the frequency of surface plasmon resonance varies depending on the size or shape of the metal nanoparticles, the dispersed solvent, etc., they can be adjusted and applied to applications using light of various wavelengths.


Gold nanoparticles (AuNPs) have been widely studied and applied in the field of tumor diagnosis and treatment because of their special fundamental properties.

Gold Cloud PAR is optimized for devices using various lights, laser, plasma, and IPL.

Schematic of plasmon oscillation for a sphere, showing the displacement of the conduction electron charge cloud relative to the nuclei.

J. Phys. Chem. B, 2003, 107, 668-677

E: electric, e: electron

Device application
Diode Laser, Fractional Laser, Laser toning


Acne, pigment, wrinkle


Applications of Gold Nanoparticles surface plasmon resonance, SPR


The SPR is an optical- electrical phenomenon that due to a charge density oscillation at the interface between a dielectric media and a metal

layer.

-Metal layer: Nano Gold

-Dielectric media: Light and frequency

Device application
Plasma Frequency


Acne, pigment


Device application
Plasma Frequency


Acne, pigment


Device application
IPL


pigment


Device application
IPL


pigment


Gold Cloud PAR-GOLD NANOPARTICLES SPR (surface plasmon resonance) THERAPY

Gold Cloud PAR; P pigment care, acne care R (wrinkle care) care solution
Gold Cloud PAR; P pigment care, acne care R (wrinkle care) care solution

Specially developed Gold Cloud PAR reduces skin inflammation, resulting strengthens skin barrier, improves skin tone, wrinkles, resilience, and pores with various skin resurfacing and skin brightening agents which are combined with ‘colloidal gold, colloidal platinum, and modified ethosomal carrier system which is exchanged alcohol to diol’ for activating plasmon resonance of skin surface and enhancing the skin penetration of skin cell nutritional and therapeutic concoction.

The point of GOLD SPR THERAPY is based on surface plasmon resonance of gold nanoparticles with device energy.

inflammation by acne
inflammation by acne
inflammation by seborrheic
inflammation by seborrheic
inflammation by pimple skin
inflammation by pimple skin
Pigments
Pigments
Wrinkles
Wrinkles
Gold and active ingredients capsulation system: Modified ethosome

Modified Ethosome

Ethosomal systems are modified from liposomes and are novel lipid vesicular carriers containing a relatively high percentage of ethanol to enhance capsule stability.


GOLD Cloud PAR’s special carrier system is a ‘Modified ethosome’ which is developed and modified capsule from ethosome, especially the alcohol was replaced to propanediol and combined with colloidal platinum and colloidal gold for specific reaction of surface plasmon resonance with energy device.



This carrier is specially designed for the efficient delivery of therapeutic agents with different physicochemical properties into deep skin layers and across the skin.

Capsulation technology

Comparison of classical ethosomes, binary ethosomes, transethosomes, and Modified Ethosomes in their initial suspension form

NMN

(β-nicotinamide mononucleotide) 

ANTI-AGING REVOLUTION 

SLOWS DOWN THE TIME OF AGING

NMN (β-nicotinamide mononucleotide) is a key of anti-aging.


As we age, metabolism—how our body converts food to energy—becomes less efficient as our cell’s powerhouses, the mitochondria, decline. As the result, the creation and utilization of cellular energy, cellular renewal, and the ability of our cells to respond to their changing environment are all impacted. 


"NMN targets metabolic aging by supplying declining metabolites and acting to preserve and help generate new mitochondria. 

Promotes healthy metabolic aging by:Increasing levels of the critical coenzyme NAD+ via the highly efficient precursor NMN,Protects and generates new mitochondria to support cellular energy."


Mitochondria play crucial roles in energy production, metabolism, apoptosis, and intracellular signaling.

Figure. Mitochondria can metabolize fuels, such as fatty acids, amino acids and pyruvate, derived from glucose.

During cellular stress or damage, mitochondria release a variety of signals to the cytosol and the nucleus to alert the cell of changes in mitochondrial function.

EFFECT OF AGING ON NAD+ LEVELS
EFFECT OF AGING ON NAD+ LEVELS

NAD+ Biosynthetic Pathways Decline With Age

FIGURE. Hypothetic molecule mechanisms of NAD+ decreased with aging. 

"Oxidative stress, DNA damage, and chronic inflammation are increased with aging, which results in accelerated NAD degradation via activation of CD38 and PARPs, or dysregulation of NAMPT.  Finally, decreased levels of NAD+ lead to various metabolic and age-associated diseases. "

Nicotinamide adenine dinucleotide (NAD) is a vital metabolic redox coenzyme found in eukaryotic cells and is necessary for over 500 enzymatic reactions.  In mammalian cells, NAD+ is synthesized predominantly through NMN, to replenish the consumption by NADase participating in physiologic processes including DNA repair, metabolism, and cell death.

NMN plays a crucial role in various biological processes, including metabolism, aging, cell death, DNA repair, and gene expression.

Oxidative DNA Damage Accumulates with Age 

DNA is vulnerable to oxidative damage which, if not repaired, can trigger mutagenesis and/or cell death via energy restriction. 

NAD+ related metabolism

Nicotinamide adenine dinucleotide (NAD+) levels in the cells deplete with aging and it is associated with downregulation of energy production in mitochondria, oxidative stress, DNA damage, and inflammatory conditions. 

However, NMN, as the precursor of NAD+, can slow down this process by elevating NAD+ levels in the body. 

Chronic inflammation and oxidative stress, which come along with aging, are the causes for reduction and inhibition of NAD+ biosynthesis. A number of in vivo studies have indicated affirmative results of therapeutic effects for various age-induced complications with NMN.

THE RESULT OF AGING

Depletion and reduction of NAD+ biosynthesis

Downregulation of energy production in mitochondria

Chronic inflammation and oxidative stress