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The Molecular Mechanisms of Ageing
The Molecular Mechanisms of Ageing

NMN (β-nicotinamide mononucleotide) is a key of anti-aging.

NMN was researched and presented in many journals like Nature, Science, and Cell metabolism as a key to anti-aging and it shows the result NMN has the effect of improving ageing.

NMN (β-nicotinamide mononucleotide) is a key of anti-aging.

NMN was researched and presented in many journals like Nature, Science, and Cell metabolism as a key to anti-aging and it shows the result NMN has the effect of improving ageing.

Aging is a time-dependent progressive decline
in biochemical and physiological function
Aging is a time-dependent progressive decline
in biochemical and physiological function

Oxidative stress plays a key role in the aging process, and oxidative. DNA damage is a major factor  associated with age related diseases. 

The human body has a number of physiological protection and repair systems, and the natural endogenous antioxidant defense system to attenuate free radical induced dagame, and thereby maintain cellular homeostasis. Essential to the PARP medicated repair of oxidative DNA damage is nicotinamide adenine denucleotide (NAD+)

✔  Mitochondria play crucial roles in energy production,metabolism, apoptosis, and intracellular signaling.

As we aged, metabolism—how our body converts food to energy—becomes less efficient as our cell’s powerhouses, the mitochondria, decline.

 As the result, the creation and utilization of cellular energy, cellular renewal, and the ability of our cells to respond to their changing environment are all impacted. 

"NMN targets metabolic aging by supplying declining metabolites and acting to preserve and help generate new mitochondria. 

Promotes healthy metabolic aging by: Increasing levels of the critical coenzyme NAD+ via the highly efficient precursor NMN,

Protects and generates new mitochondria to support cellular energy."

Nicotinamide adenine dinucleotide (NAD+) levels in the cells deplete with aging and it is associated with downregulation of energy production in mitochondria, oxidativestress, DNA damage, and inflammatory conditions. However, NMN, as the precursor of NAD+, can slow down this process by elevating NAD+ levels in the body. Chronic inflammation and oxidatives stress, which come along with aging, are the causes for reduction and inhibition of NAD+ biosynthesis. A number of in vivo studies have indicated affirmative results of therapeytic effects for various age-induced complications with NMN.

Trends in Biochemical Sciences, December 2010, Vol. 35, No.12

EFFECT OF AGING ON
NAD+ LEVELS NAD+ Biosynthetic Pathways Decline With Age

Figure. Hypothetic molecule mechanisms of NAD+ decreased with aging.

"Oxidative stress, DNA damage, and chronic inflammation are increased with aging, which results in accelerated NAD degradation via activation of CD38 and PARPs, or dysregulation of NAMPT. Finally, decreased levels of NAD+ lead to various metabolic and age-associated diseases. "

✔ Oxidative DNA Damage Accumulates with Age

   DNA is vulnerable to oxidative damage which, if not repaired, can trigger mutagenesis and/or cell death via energy restriction. 

Phosphorylated-H2AX as a marker for DNA

Phosphorylated-H2AX as a marker for DNA damage in male subjects show a significant correlation with age. Line a represents the correlation for subjects aged between 0–77 years (p = 0.0095; n = 27). Line b shows post-pubescent data (males only) (p = 0.0286; n = 19).

Phosphorylated-H2AX as a marker for DNA

Damage in post-pubescent female subjects shows a significant positive correlation with age (36–76 years) (p = 0.003; n = 22).

✔ Mitochondria play crucial roles in energy production, metabolism, apoptosis, and intracellular signaling.

As we age, metabolism—how our body converts food to energy—becomes less efficient as our cell’s powerhouses, the mitochondria, decline. As the result, the creation and utilization of cellular energy, cellular renewal, and the ability of our cells to respond to their changing environment are all impacted. 

"NMN targets metabolic aging by supplying declining metabolites and acting to preserve and help generate new mitochondria.

Promotes healthy metabolic aging by:Increasing levels of the critical coenzyme NAD+ via the highly efficient precursor NMN,Protects and generates new mitochondria to support cellular energy."

Nicotinamide adenine dinucleotide (NAD) is a vital metabolic redox coenzyme found in eukaryotic cells and is necessary for over 500 enzymatic reactions.  In mammalian cells, NAD+ is synthesized predominantly through NMN, to replenish the consumption by NADase participating in physiologic processes including DNA repair, metabolism, and cell death.

NMN plays a crucial role in various biological processes, including metabolism, aging, cell death, DNA repair, and gene expression.

Trends in Biochemical Sciences, December 2010, Vol.35, No.12



NMN (β-nicotinamide mononucleotide) is improves epidermal skin thickness.

The thickness of the whole skin layer was significantly thicker in the mice in the NMN+UVB group than in those in the UVB group.



NMN (β-nicotinamide mononucleotide) improves dermal skin thickness

The thickness of the whole skin layer was significantly thicker in the mice in the NMN+UVB group than in those in the UVB group.


✔ Caviar extract


NMN (β-nicotinamide mononucleotide) reduces inflammatory reaction.

"According to the Toluidine blue staining results, significantly more mast cells were present in the dermal layer in the UVB group (p < 0.05), indicating that UVB irradiation induced the production of mast cells in the skin, thereby resulting in skin inflammation. 

The VC+UVB group showed decreased mast cells in mouse skin than the UVB group. After the mice were treated with NMN, the mast cells in mouse skin were significantly reduced (p< 0.05), and the results were similar to the control group."



Caviar extract and DHA induce adipocyte differentiation and adiponectin production, thereby inhibition UVB-induced premature skin aging via the suppression of MMP-1 production.


Caviar extract contributes to an increase in adipocyte differentiation. The results showed that the caviar extract enhanced adipocyte differentiation by an increase in both intracellular lipid accumulation and gene expression levels of adipogensis-related transcription factors. 

✔ Biomimetic Peptide Combination

                 Nanopeptide-1 for reducing pigmentation

                                                                                LUCAS MEYER: MELANOSTATINE 5

                  Acetyl hexapeptide-8 has been used in anti-aging used in topical 

                  formulations aimed at improving skin appearance.

                     Brazilizn Journal of Pharmaceutical Sciences vol. 51, n.4, oct./dec., 2015

NMN (Nicotinamide mononucleotide) SKINCARE
The solution of skin aging.
Skin cell revitalizing nutritional bioconcoction
NMN (Nicotinamide mononucleotide) SKINCARE
The solution of skin aging.
Skin cell revitalizing nutritional bioconcoction
EFFECT OF AGING ON NAD+ LEVELS
EFFECT OF AGING ON NAD+ LEVELS

Figure. Hypothetic molecule mechanisms of NAD+ decreased with aging.

"Oxidative stress, DNA damage, and chronic inflammation are increased with aging, which results in accelerated NAD degradation via activation of CD38 and PARPs, or dysregulation of NAMPT.  Finally, decreased levels of NAD+ lead to various metabolic and age-associated diseases. "

✔ Oxidative DNA Damage Accumulates with Age 

DNA is vulnerable to oxidative damage which, if not repaired, can trigger mutagenesis and/or cell death via energy restriction.

NMN (β-nicotinamide mononucleotide) is improves epidermal skin thickness.

The thickness of the whole skin layer was significantly thicker in the mice in the NMN+UVB group than in those in the UVB group.

NMN (β-nicotinamide mononucleotide) improves dermal skin thickness

The thickness of the whole skin layer was significantly thicker in the mice in the NMN+UVB group than in those in the UVB group.

NMN (β-nicotinamide mononucleotide) reduces inflammatory reaction.

"According to the Toluidine blue staining results, significantly more mast cells were present in the dermal layer in the UVB group (p < 0.05), indicating that UVB irradiation induced the production of mast cells in the skin, thereby resulting in skin inflammation. The VC+UVB group showed decreased mast cells in mouse skin than the UVB group. After the mice were treated with NMN, the mast cells in mouse skin were significantly reduced (p< 0.05), and the results were similar to the control group."

✔ Caviar extract

Caviar extract and DHA induce adipocyte differentiation and adiponectin production, thereby inhibition UVB-induced premature skin aging via the suppression of MMP-1 production.


Caviar extract contributes to an increase in adipocyte differentiation. The results showed that the caviar extract enhanced adipocyte differentiation by an increase in both intracellular lipid accumulation and gene expression levels of adipogensis-related transcription factors.

✔ Biomimetic Peptide Combination

Nanopeptide-1 for reducing pigmentation

                                                                       LUCAS MEYER: MELANOSTATINE 5

Acetyl hexapeptide-8 has been used in anti-aging used in topical formulations aimed at improving skin appearance.

      Brazilizn Journal of Pharmaceutical Sciences vol. 51, n.4, oct./dec., 2015

NMN skincare
The solution of skin aging.
skin cell revitalizing nutritional bioconcoction.
NMN skincare
The solution of skin aging.
skin cell revitalizing nutritional bioconcoction.