NMN

The story of NMN

<LifeSpan-Why We Age, and Why We Don't Have To> by David A. Sinclair, Ph. D.

"A NEW YORK TIMES BESTSELLER

“Brilliant and enthralling.” —The Wall Street Journal"

< LifeSpan-Why We Age, and Why We Don't Have To> by David A. Sinclair, Ph. D.

A NEW YORK TIMES BESTSELLER

“Brilliant and enthralling.” —The Wall Street Journal


Why We Age? And Why We Don't Have To. 
The Molecular Mechanisms of Ageing.


NMN

(β-nicotinamide mononucleotide) 

ANTI-AGING REVOLUTION 

SLOWS DOWN THE TIME OF AGING


NMN (β-nicotinamide mononucleotide) is a key of anti-aging.

NMN (β-Nicotinamide mononucleotide), NMN was researched and presented in many journals like Nature, Science, and Cell metabolism 

as a key to anti-aging and it shows the result NMN has the effect of improving ageing.You should follow us on Twitter to post something

NMN (β-nicotinamide mononucleotide) is a key of anti-aging.


As we age, metabolism—how our body converts food to energy—becomes less efficient as our cell’s powerhouses, the mitochondria, decline. As the result, the creation and utilization of cellular energy, cellular renewal, and the ability of our cells to respond to their changing environment are all impacted. 


"NMN targets metabolic aging by supplying declining metabolites and acting to preserve and help generate new mitochondria. 

Promotes healthy metabolic aging by:Increasing levels of the critical coenzyme NAD+ via the highly efficient precursor NMN,Protects and generates new mitochondria to support cellular energy."


Mitochondria play crucial roles in energy production, metabolism, apoptosis, and intracellular signaling.

Figure. Mitochondria can metabolize fuels, such as fatty acids, amino acids and pyruvate, derived from glucose.

During cellular stress or damage, mitochondria release a variety of signals to the cytosol and the nucleus to alert the cell of changes in mitochondrial function.

NAD+ related metabolism

Nicotinamide adenine dinucleotide (NAD+) levels in the cells deplete with aging and it is associated with downregulation of energy production in mitochondria, oxidative stress, DNA damage, and inflammatory conditions. 

However, NMN, as the precursor of NAD+, can slow down this process by elevating NAD+ levels in the body. 

Chronic inflammation and oxidative stress, which come along with aging, are the causes for reduction and inhibition of NAD+ biosynthesis. A number of in vivo studies have indicated affirmative results of therapeutic effects for various age-induced complications with NMN.


EFFECT OF AGING ON NAD+ LEVELS
EFFECT OF AGING ON NAD+ LEVELS

NAD+ Biosynthetic Pathways Decline With Age

FIGURE. Hypothetic molecule mechanisms of NAD+ decreased with aging. 

"Oxidative stress, DNA damage, and chronic inflammation are increased with aging, which results in accelerated NAD degradation via activation of CD38 and PARPs, or dysregulation of NAMPT.  Finally, decreased levels of NAD+ lead to various metabolic and age-associated diseases. "

Nicotinamide adenine dinucleotide (NAD) is a vital metabolic redox coenzyme found in eukaryotic cells and is necessary for over 500 enzymatic reactions.  In mammalian cells, NAD+ is synthesized predominantly through NMN, to replenish the consumption by NADase participating in physiologic processes including DNA repair, metabolism, and cell death.

NMN plays a crucial role in various biological processes, including metabolism, aging, cell death, DNA repair, and gene expression.

Oxidative DNA Damage Accumulates with Age 

DNA is vulnerable to oxidative damage which, if not repaired, can trigger mutagenesis and/or cell death via energy restriction. 

NAD+ related metabolism

Nicotinamide adenine dinucleotide (NAD+) levels in the cells deplete with aging and it is associated with downregulation of energy production in mitochondria, oxidative stress, DNA damage, and inflammatory conditions. 

However, NMN, as the precursor of NAD+, can slow down this process by elevating NAD+ levels in the body. 

Chronic inflammation and oxidative stress, which come along with aging, are the causes for reduction and inhibition of NAD+ biosynthesis. A number of in vivo studies have indicated affirmative results of therapeutic effects for various age-induced complications with NMN.

THE RESULT OF AGING

Depletion and reduction of NAD+ biosynthesis

Downregulation of energy production in mitochondria

Chronic inflammation and oxidative stress


NMN (β-nicotinamide mononucleotide) is a key of anti-aging.