pH Therapy

The story of NMN

<LifeSpan-Why We Age, and Why We Don't Have To> by David A. Sinclair, Ph. D.

"A NEW YORK TIMES BESTSELLER

“Brilliant and enthralling.” —The Wall Street Journal"

pH THERAPY?

"Skin surface pH increases by aging,

various exogenous and endogenous factors.

The function of the skin barrier, enzymes,

and metabolic factors decrease

in high pH and skin, microflora affects."


   pH therapy slows the regain of healthy skin pH by multiple steps of treatment in 2cyles of the epidermis (≒2 months).


pH therapy is for;

- Gradually clean by soft melting the surface of the skin 

- Preparing the skin surface for helping absorbance 

   of active ingredients.

- Reduces the stress on the skin in time-dependent 

  therapy following 2 cycles of skin.



Image reblogged from approachingsignificance tumblr (link).   SEM Epidermis photograph by Andrew Syred
Image reblogged from approachingsignificance tumblr (link).   SEM Epidermis photograph by Andrew Syred

PICTURE OF SKIN SURFACE

The epidermis is a tough coating formed from overlapping layers of dead skin cells.

pH therapy skincare in turn minimizes inflammation and redness, stabilizes the microbiome, reduces dryness, and maintains the integrity of the skin. pH therapy is formulated to the optimal pH for efficacy, safety, and biocompatibility.

The Serums are the purest formulations, they are designed to treat specific skin imbalances (dehydrated, devitalized, fine-lined, seborrheic skin, etc.). The serums can be used alone or combined for the best result. 


pH therapy Serums are specifically formulated for different skin types, and the formulations are developed to enhance the absorption of active ingredients.  

Each specific serum is formulated to be adopted in each skin condition, the skin is improved by treatment of each serum care, and it renews the skin about two epidermal cycles for a gentle, effective nutriments process.

The specific formulations of each serum are developed in skin-friendly composition, which was minimized skin irritation, and slowly improves skin health rather than for instant effect with stressful conditions, to be followed fluxomics of skin metabolomics to attempt subtle change.

This is made possible by the RADKIN program, the world’s first therapy procedure with skin cell-nutrition care!

This new skin cell metabolomics base therapy provides you with daily personalized skin-nutritional care and ensures you are reaching your healthy skin.

NMN

(β-nicotinamide mononucleotide) 

ANTI-AGING REVOLUTION 

SLOWS DOWN THE TIME OF AGING

NMN (β-nicotinamide mononucleotide) is a key of anti-aging.


As we age, metabolism—how our body converts food to energy—becomes less efficient as our cell’s powerhouses, the mitochondria, decline. As the result, the creation and utilization of cellular energy, cellular renewal, and the ability of our cells to respond to their changing environment are all impacted. 


"NMN targets metabolic aging by supplying declining metabolites and acting to preserve and help generate new mitochondria. 

Promotes healthy metabolic aging by:Increasing levels of the critical coenzyme NAD+ via the highly efficient precursor NMN,Protects and generates new mitochondria to support cellular energy."


Mitochondria play crucial roles in energy production, metabolism, apoptosis, and intracellular signaling.

Figure. Mitochondria can metabolize fuels, such as fatty acids, amino acids and pyruvate, derived from glucose.

During cellular stress or damage, mitochondria release a variety of signals to the cytosol and the nucleus to alert the cell of changes in mitochondrial function.

EFFECT OF AGING ON NAD+ LEVELS
EFFECT OF AGING ON NAD+ LEVELS

NAD+ Biosynthetic Pathways Decline With Age

FIGURE. Hypothetic molecule mechanisms of NAD+ decreased with aging. 

"Oxidative stress, DNA damage, and chronic inflammation are increased with aging, which results in accelerated NAD degradation via activation of CD38 and PARPs, or dysregulation of NAMPT.  Finally, decreased levels of NAD+ lead to various metabolic and age-associated diseases. "

Nicotinamide adenine dinucleotide (NAD) is a vital metabolic redox coenzyme found in eukaryotic cells and is necessary for over 500 enzymatic reactions.  In mammalian cells, NAD+ is synthesized predominantly through NMN, to replenish the consumption by NADase participating in physiologic processes including DNA repair, metabolism, and cell death.

NMN plays a crucial role in various biological processes, including metabolism, aging, cell death, DNA repair, and gene expression.

Oxidative DNA Damage Accumulates with Age 

DNA is vulnerable to oxidative damage which, if not repaired, can trigger mutagenesis and/or cell death via energy restriction. 

NAD+ related metabolism

Nicotinamide adenine dinucleotide (NAD+) levels in the cells deplete with aging and it is associated with downregulation of energy production in mitochondria, oxidative stress, DNA damage, and inflammatory conditions. 

However, NMN, as the precursor of NAD+, can slow down this process by elevating NAD+ levels in the body. 

Chronic inflammation and oxidative stress, which come along with aging, are the causes for reduction and inhibition of NAD+ biosynthesis. A number of in vivo studies have indicated affirmative results of therapeutic effects for various age-induced complications with NMN.

THE RESULT OF AGING

Depletion and reduction of NAD+ biosynthesis

Downregulation of energy production in mitochondria

Chronic inflammation and oxidative stress