TAC HAIR Therapy

The story of NMN

<LifeSpan-Why We Age, and Why We Don't Have To> by David A. Sinclair, Ph. D.

"A NEW YORK TIMES BESTSELLER

“Brilliant and enthralling.” —The Wall Street Journal"

The Anatomy of Hair

  TAC Scalp Skin Care Science

   -Holistic Nutrient series

Hair thinning and baldness are common conditions and although more prevalent in older generations, hair loss can be triggered at anytime throughout our life. 

Factors of hair loss: Stress, genetics, life style, and hormones, etc.

Hair thinning and falling


Hair the signaling pathway is started from oxidative stress reaction, and it is getting worse by increasing cell damage include DNA damage and cell death,  less nutrition by degeneration of blood vessels result  hair fall and thin scalp.

Science 05 Feb 2016: Vol. 351, Issue 6273, aad4395
Science 05 Feb 2016: Vol. 351, Issue 6273, aad4395

How much hair loss is normal?

The average woman loses between 50 and 100 strands per day, even up to 150 in some cases. Total hair number is 90K~150K in adult, and the density of follicle is 80~120follicles per square centimeter, that means 170~220 strands per square centimeter. NH index 5~6 means 25~50% of hair loss, the number of lost hairs will be around 25K~75K strands. Try to do calculate how much we need to pay for hair transplantation to recover upto 95% of hairs.


According to the research, it is normal to lose 50-100 hairs every day. This may sound like a lot, but keep in mind that we have 90,000 to 150,000 feathers.

NMN

(β-nicotinamide mononucleotide) 

ANTI-AGING REVOLUTION 

SLOWS DOWN THE TIME OF AGING

   True hair loss occurs when lost hairs are not regrown or when    the daily hair shed exceeds 125hairs. 

   The average women loses between 50 and 100 strands per day, 

   even up to 150 in some cases. Man will lose between  25- 100 hairs a day.

  TAC Scalp Skin Care Science  


  Holistic Nutrient Shampoo, 93ml

  Cleans and provide 1st step nutriment combination.

  >> Wash hair and scalp and wash off foam.

  Holistic Nutrient Conditioner for Scalp, 93ml

  Moisturizes and provide 2nd step nutriment combination.

  >> Put it on scalp for 3minutes and wash it off.

  Holistic Nutrient Serum for Scalp, 30ml

  Provides sufficient concentration of nutriment combination for intensive care for     scalp and hair.

  >> Apply serum twice daily in the morning and night.

  Leave it on your scalp at least 10minutes.

TAC SCALP care is composed of shampoo, scalp moisturizer, and serum, Scalp serum is the main nutriment complex, and Shampoo and scalp moisturizer are activators at the beginning stage of treatment. I recommend using shampoo and conditioner at the beginning of treatment, 1st ~2nd months.

Restoring Scalp skin cells and hair follicle stem cells are the key for regrowth of hairs.

Hair follicle cell development

Sarah E Millar An ideal society? Neighbors of diverse origins interact to create and maintain complex mini-organs in the skin. PLoS Biol.: 2005, 3(11);e372 PubMed 16277556
Sarah E Millar An ideal society? Neighbors of diverse origins interact to create and maintain complex mini-organs in the skin. PLoS Biol.: 2005, 3(11);e372 PubMed 16277556

Inside of scalp tissue has hair root stem cells, when hair is going to falling phase, Telogen, there should be happened differentiated from hair root stem cells to go to the growth phase. But when the hair loss pathway is triggered by an irregular aging process, scalp skin cells and stem cells have degenerated.

TAC is a specially designed ingredient component for scalp restoring,

Hair is restored through the reverse direction of hair drop by TAC through scalp remodeling and new hair formation progress.

TAC SCIENCE SCALP CARE
TAC SCIENCE SCALP CARE

Combination of

Plant stem cells

+Phytochemical conjugated Peptides

+Neuropeptides

+Gallic acid

+Vitamins

+Trace elements

+Natural oils

Fight against

ROS

Free radicals

Inflammation

Cell death

 

Enhancing

Cell vitality

Normalizing

Cell cycle

NMN (β-nicotinamide mononucleotide) is a key of anti-aging.


As we age, metabolism—how our body converts food to energy—becomes less efficient as our cell’s powerhouses, the mitochondria, decline. As the result, the creation and utilization of cellular energy, cellular renewal, and the ability of our cells to respond to their changing environment are all impacted. 


"NMN targets metabolic aging by supplying declining metabolites and acting to preserve and help generate new mitochondria. 

Promotes healthy metabolic aging by:Increasing levels of the critical coenzyme NAD+ via the highly efficient precursor NMN,Protects and generates new mitochondria to support cellular energy."


Mitochondria play crucial roles in energy production, metabolism, apoptosis, and intracellular signaling.

Figure. Mitochondria can metabolize fuels, such as fatty acids, amino acids and pyruvate, derived from glucose.

During cellular stress or damage, mitochondria release a variety of signals to the cytosol and the nucleus to alert the cell of changes in mitochondrial function.

EFFECT OF AGING ON NAD+ LEVELS
EFFECT OF AGING ON NAD+ LEVELS

NAD+ Biosynthetic Pathways Decline With Age

FIGURE. Hypothetic molecule mechanisms of NAD+ decreased with aging. 

"Oxidative stress, DNA damage, and chronic inflammation are increased with aging, which results in accelerated NAD degradation via activation of CD38 and PARPs, or dysregulation of NAMPT.  Finally, decreased levels of NAD+ lead to various metabolic and age-associated diseases. "

Nicotinamide adenine dinucleotide (NAD) is a vital metabolic redox coenzyme found in eukaryotic cells and is necessary for over 500 enzymatic reactions.  In mammalian cells, NAD+ is synthesized predominantly through NMN, to replenish the consumption by NADase participating in physiologic processes including DNA repair, metabolism, and cell death.

NMN plays a crucial role in various biological processes, including metabolism, aging, cell death, DNA repair, and gene expression.

Oxidative DNA Damage Accumulates with Age 

DNA is vulnerable to oxidative damage which, if not repaired, can trigger mutagenesis and/or cell death via energy restriction. 

NAD+ related metabolism

Nicotinamide adenine dinucleotide (NAD+) levels in the cells deplete with aging and it is associated with downregulation of energy production in mitochondria, oxidative stress, DNA damage, and inflammatory conditions. 

However, NMN, as the precursor of NAD+, can slow down this process by elevating NAD+ levels in the body. 

Chronic inflammation and oxidative stress, which come along with aging, are the causes for reduction and inhibition of NAD+ biosynthesis. A number of in vivo studies have indicated affirmative results of therapeutic effects for various age-induced complications with NMN.

THE RESULT OF AGING

Depletion and reduction of NAD+ biosynthesis

Downregulation of energy production in mitochondria

Chronic inflammation and oxidative stress